What is the recommended dosage for Niacinamide?

General: 14-16 mg/day NE (RDA); Skin Health: 500-1,500 mg/day oral nicotinamide

What are the side effects of Niacinamide?

Potential side effects include: Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day).

What is niacinamide and how may it support skin health?

Niacinamide (nicotinamide, vitamin B3) is well-studied for skin benefits both topically and orally. It supports the skin barrier by increasing ceramide production, has anti-inflammatory effects, and may reduce melanin transfer to keratinocytes. A landmark RCT showed oral nicotinamide reduced non-melanoma skin cancer rates by 23%.

What dosage of niacinamide has been studied for skin benefits?

The skin cancer prevention trial used 500 mg of oral nicotinamide twice daily (1,000 mg/day). For skin barrier and anti-inflammatory effects, topical studies typically use 2–5% concentrations. Oral supplementation at 500–1,500 mg daily has been studied for acne and rosacea with some positive results.

What are the potential side effects of niacinamide supplements?

Niacinamide is generally well tolerated and does not cause the flushing associated with niacin (nicotinic acid). Mild gastrointestinal effects may occur at higher doses. Very high doses (above 3,000 mg daily) may cause liver toxicity. Niacinamide does not significantly affect lipid profiles, unlike niacin.

Niacinamide
Niacinamide

vitamin

Também conhecido como: Nicotinamide, Vitamin B3, Niacin amide

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About

Niacinamide is the amide form of vitamin B3 that supports NAD+/NADH coenzyme production, strengthens the epidermal lipid barrier by stimulating ceramide and fatty acid synthesis, and inhibits melanosome transfer from melanocytes to keratinocytes. The landmark ONTRAC trial found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% in high-risk individuals.

How It Works

Amide form of vitamin B3 that supports NAD+/NADH coenzyme production; strengthens the epidermal lipid barrier by stimulating ceramide and fatty acid synthesis; inhibits melanosome transfer from melanocytes to keratinocytes (reducing hyperpigmentation); suppresses NF-kB-mediated inflammatory pathways in skin.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Acne	A	15	1200	Ver →
UV Protection (Internal Photoprotection)	A	5	686	Ver →

Side Effects

Generally well-tolerated (no flushing unlike niacin)
Mild gastrointestinal discomfort at high doses
Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Drug & Supplement Interactions

Anticonvulsants (carbamazepine — may increase niacinamide levels)
Hepatotoxic drugs (potential additive liver effect at high doses)
Isoniazid (competes for NAD+ pathways)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Vitamin C Vitamin E Vitamin A (Retinol) Vitamin D Biotin

Dados Rápidos

Dosagem: General: 14-16 mg/day NE (RDA); Skin_Health: 500-1,500 mg/day oral nicotinamide
Formas: capsule tablet topical
Fontes Naturais: Poultry, Fish, Mushrooms, Green peas, Fortified cereals, Peanuts
Limite Superior: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
Melhor Horário: With meals; can be split into 2-3 doses

Resumo das Evidências

Acne A

UV Protection (Internal Photoprotection) A

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.