Nicotinamide para UV Protection (Internal Photoprotection)
A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).
Conclusão
At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).
Key Study Findings
População: Overview of reviews on niacin/nicotinamide adverse effects
População: High-risk NMSC patients (RCTs)
População: None
População: General population (cosmetic users)
Key Statistics
5
Estudos
686
Participantes
Positive
Nota
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- generalskinbarrier:
- 500-1,500 mg/day
- skincancerchemoprevention:
- 500 mg twice daily (1,000 mg/day total)
Limite superior: Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
Melhor horário: With meals; split into 2 doses for chemoprevention
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Generally well-tolerated (no flushing)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses
Interações Conhecidas
- ● Anticonvulsants (carbamazepine — may increase levels)
- ● Isoniazid (competes for NAD+ pathways)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
Ingestão máxima tolerável: Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Nicotinamide help with UV Protection (Internal Photoprotection)?
How much Nicotinamide should I take for UV Protection (Internal Photoprotection)?
Are there side effects of Nicotinamide?
How strong is the evidence for Nicotinamide and UV Protection (Internal Photoprotection)?
Related Evidence
Outros ingredientes para UV Protection (Internal Photoprotection)
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [3] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [4] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [5] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.