What is the recommended dosage for Polypodium leucotomos?

General: 240-480 mg/day; Photoprotection: 480 mg/day (240 mg twice daily, 30-60 min before sun exposure)

What are the side effects of Polypodium leucotomos?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort (rare), Pruritus (rare).

What is Polypodium leucotomos and how may it support skin health?

Polypodium leucotomos extract (PLE, Fernblock) is derived from a tropical fern with demonstrated photoprotective properties. Multiple RCTs show oral PLE reduces UV-induced skin damage, erythema, and DNA damage. It is used as a systemic photoprotection supplement and has been studied for preventing polymorphic light eruption and melasma.

What dosage of Polypodium leucotomos has been studied for sun protection?

Clinical studies have used 240–480 mg of PLE per day, typically taken 30 minutes before sun exposure. A common dose is 240 mg twice daily. Studies show PLE increases the minimal erythema dose (MED) by approximately 2–3 fold, providing supplemental UV protection. It does not replace topical sunscreen.

What are the potential side effects of Polypodium leucotomos?

PLE is generally well tolerated in clinical trials with no significant adverse events reported. Mild gastrointestinal discomfort has been noted. It should not be used as a substitute for sunscreen or sun-protective clothing. Individuals with fern allergies should exercise caution. Long-term safety data beyond 6 months is limited.

Polypodium leucotomos
Polypodium leucotomos

specialty

다른 이름: PLE, Fernblock, Heliocare, Calaguala, Anapsos

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About

Polypodium leucotomos is a tropical fern extract that reduces UV-induced oxidative stress and DNA damage. A systematic review of 5 RCTs found oral PLE significantly increased the minimal erythema dose (MED) by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

How It Works

Tropical fern extract rich in phenolic compounds that reduce UV-induced oxidative stress; inhibits MMP-1 expression; suppresses UV-mediated COX-2 and AP-1 activation; reduces UV-induced DNA damage (cyclobutane pyrimidine dimers); may modulate Langerhans cell depletion from UV exposure.

Evidence For Conditions

건강 상태	등급	연구	참여자
UV Protection (Internal Photoprotection)	B	5	250	보기 →
Hyperpigmentation	C	3	150	보기 →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort (rare)
Pruritus (rare)

Drug & Supplement Interactions

Immunosuppressants (may modulate immune function)
Photosensitizing medications (may modulate UV response)

복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.

Related Ingredients

Pine Bark Extract (Pycnogenol) Nicotinamide MSM

핵심 정보

용량: General: 240-480 mg/day; Photoprotection: 480 mg/day (240 mg twice daily, 30-60 min before sun exposure)
제형: capsule tablet
천연 원료: Polypodium leucotomos fern (Central and South American tropical fern)
상한 섭취량: Generally well-tolerated up to 960 mg/day
권장 복용 시간: 30-60 minutes before sun exposure; can also be taken daily for baseline protection

근거 요약

UV Protection (Internal Photoprotection) B

Hyperpigmentation C

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.