Omega-3 Fatty Acids ： Psoriasis
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。Some RCTs suggest omega-3 supplementation may modestly improve psoriasis severity through anti-inflammatory effects, but results are inconsistent across trials.
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D
結論
Some RCTs suggest omega-3 supplementation may modestly improve psoriasis severity through anti-inflammatory effects, but results are inconsistent across trials.
Key Study Findings
Review
Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of naturally derived bioactive compounds for psoriasis (flavonoids, terpenoids, omega-3, alkaloids)
Review
Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Patients with acne, HS, or psoriasis
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
vs: None
Outcome: Colitis severity
効果: None
None
対象集団: Crohn's disease patients
narrative_review
Nutrition and skin: Kids are not just little people.
Dose: None
vs: Placebo
効果: narrative review; discusses role of nutrition from prenatal period on skin immune responses; highlig
not_applicable
Other
In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular …
Dose: 100 mg
vs: control
Outcome: None
効果: None
None
対象集団: psoriasis patients
Review
Diet and psoriasis, part III: role of nutritional supplements.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: psoriasis patients
Key Statistics
6
研究数
400
参加者数
↑
Positive
D
グレード
Referenced Papers
Inflammopharmacology
2025
26 件の引用
Current obesity reports
2025
Autoimmunity reviews
2024
12 件の引用
Journal of cosmetic …
2022
30 件の引用
Clinics in dermatology
2016
19 件の引用
FEBS open bio
2016
1 件の引用
Journal of the …
2014
93 件の引用
Current atherosclerosis reports
2004
464 件の引用
Journal of the …
2002
2016 件の引用
Drugs
1998
99 件の引用
Arquivos de gastroenterologia
1996
The American journal …
1991
2278 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg combined EPA/DHA per day
- skinhealth:
- 1,000-2,000 mg/day EPA+DHA
上限量： 3,000 mg/day combined EPA/DHA (FDA GRAS)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| 100 mg | -- | Mixed | -- |
| None | -- | Positive | -- |
| EPA and DHA | -- | Positive | -- |
| Omega-3 fatty acids (EPA, DHA) | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
耐容上限摂取量： 3,000 mg/day combined EPA/DHA (FDA GRAS)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Omega-3 Fatty Acids help with Psoriasis?
Based on 6 studies with 400 participants, there is preliminary evidence that needs more research that Omega-3 Fatty Acids may support Psoriasis management. Our evidence grade is D (Very Early Research).
How much Omega-3 Fatty Acids should I take for Psoriasis?
Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids and Psoriasis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Psoriasis
Omega-3 Fatty Acids 他の症状・状態について
References
- [1] Ada Radu et al.. Inflammopharmacology. 2025. Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions. doi:10.1007/s10787-024-01602-z PubMed
- [2] Luigi Barrea et al.. Curr Obes Rep. 2025. Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), … doi:10.1007/s13679-025-00630-2 PubMed
- [3] Kimsor Hong et al.. Autoimmun Rev. 2024. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. doi:10.1016/j.autrev.2024.103651 PubMed
- [4] Kabir Sardana et al.. J Cosmet Dermatol. 2022. Role of nutritional supplements in selected dermatological disorders: A review. doi:10.1111/jocd.14436 PubMed
- [5] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [6] Mohd Hanif Zulfakar et al.. FEBS Open Bio. 2016. In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular markers and macrophages. doi:10.1002/2211-5463.12095 PubMed
- [7] Jillian W Millsop et al.. J Am Acad Dermatol. 2014. Diet and psoriasis, part III: role of nutritional supplements. doi:10.1016/j.jaad.2014.03.016 PubMed
- [8] Trevor A Mori et al.. Curr Atheroscler Rep. 2004. Omega-3 fatty acids and inflammation. doi:10.1007/s11883-004-0087-5 PubMed
- [9] Artemis P Simopoulos. J Am Coll Nutr. 2002. Omega-3 fatty acids in inflammation and autoimmune diseases. doi:10.1080/07315724.2002.10719248 PubMed
- [10] A Heller et al.. Drugs. 1998. Lipid mediators in inflammatory disorders. doi:10.2165/00003495-199855040-00001 PubMed
- [11] C Cukier et al.. Arq Gastroenterol. 1996. [Biological activity of fish oil]. PubMed
- [12] A P Simopoulos. Am J Clin Nutr. 1991. Omega-3 fatty acids in health and disease and in growth and development. doi:10.1093/ajcn/54.3.438 PubMed
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。