Keratin ： Hair, Skin & Nails Health
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。Limited evidence from small RCTs suggests solubilized keratin (500 mg/day) may improve skin moisture and elasticity, but most studies use proprietary extracts.
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D
結論
Limited evidence from small RCTs suggests solubilized keratin (500 mg/day) may improve skin moisture and elasticity, but most studies use proprietary extracts.
Key Study Findings
Other
TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis.
Dose: None
vs: untreated controls
Outcome: hair follicle transition from telogen to anagen phase
効果: None
None
対象集団: female and male rats, naturally aged and DHT-induced alopecia model mice
review
Nail Supplements: When, How, and Why?
Dose: biotin, collagen peptides, solubilized keratin MSM, choline-stabilized orthosilicic acid
vs: Placebo
効果: None
None
in vitro/ex vivo study
A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond …
Dose: USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu
vs: Placebo
効果: USPlus DERM IC50=0.39 μg/mL (vs 29.1 μg/mL standard extract); 0.4 μg/mL significantly reduced melani
None
Other
AP collagen peptides (APCPs) promote hair growth by activating the GSK-3β/β-catenin pathway and improve hair …
Dose: None
vs: None
Outcome: Hair growth
効果: None
None
対象集団: Mouse model
Review
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Dose: None
vs: None
Outcome: Hair regrowth
効果: None
None
対象集団: Alopecia patients
Case-control
n=60
Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss.
Dose: None
vs: Placebo
効果: OR=12.6 (CC genotype Taq-1), OR=7.5 (AA genotype Cdx-1)
None
Key Statistics
2
研究数
120
参加者数
↑
Positive
D
グレード
Referenced Papers
Biochemical pharmacology
2026
Frontiers in bioengineering …
2025
8 件の引用
International journal of …
2025
1 件の引用
Skin appendage disorders
2025
Experimental dermatology
2024
5 件の引用
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Review
Regenerative therapy
2022
96 件の引用
Experimental dermatology
2020
10 件の引用
Indian journal of …
2020
5 件の引用
Nutrients
2019
23 件の引用
Skin appendage disorders
2018
88 件の引用
Journal of medicinal …
2018
37 件の引用
Journal of photochemistry …
2018
16 件の引用
Stem cell investigation
2017
53 件の引用
TheScientificWorldJournal
2014
14 件の引用
Experimental dermatology
2003
35 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg/day solubilized keratin
上限量： Not established
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| biotin, collagen peptides, solubilized keratin MSM, choline-stabilized orthosilicic acid | -- | Positive | -- |
| USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 60 |
| None | -- | Mixed | -- |
| None | 8.7 weeks | Positive | -- |
推奨摂取タイミング： With meals
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated
- ⚠ Rare gastrointestinal discomfort
既知の相互作用
- ● No significant drug interactions documented
耐容上限摂取量： Not established
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Keratin help with Hair, Skin & Nails Health?
Based on 2 studies with 120 participants, there is preliminary evidence that needs more research that Keratin may support Hair, Skin & Nails Health management. Our evidence grade is D (Very Early Research).
How much Keratin should I take for Hair, Skin & Nails Health?
Studies have used various dosages. A commonly studied range is 250-500 mg/day solubilized keratin. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Keratin?
Reported side effects may include Generally well-tolerated, Rare gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Keratin and Hair, Skin & Nails Health?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 120 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Hair, Skin & Nails Health
References
- [1] Majid Manzoor et al.. Biochem Pharmacol. 2026. TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis. doi:10.1016/j.bcp.2026.117764 PubMed
- [2] Yukun Liu et al.. Front Bioeng Biotechnol. 2025. Subcutaneous injection of genetically engineered exosomes for androgenic alopecia treatment. doi:10.3389/fbioe.2025.1614090 PubMed
- [3] David Broadley et al.. Int J Cosmet Sci. 2025. A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: Insights from … doi:10.1111/ics.70035 PubMed
- [4] Ines Zaraa et al.. Skin Appendage Disord. 2025. Nail Supplements: When, How, and Why? doi:10.1159/000541048 PubMed
- [5] Jung Ok Lee et al.. Exp Dermatol. 2024. AP collagen peptides (APCPs) promote hair growth by activating the GSK-3β/β-catenin pathway and improve hair condition. doi:10.1111/exd.15137 PubMed
- [6] Yusuke Shimizu et al.. Regen Ther. 2022. Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature. doi:10.1016/j.reth.2022.10.005 PubMed
- [7] Ralf Paus et al.. Exp Dermatol. 2020. Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? doi:10.1111/exd.14156 PubMed
- [8] Iman Seleit et al.. Indian J Dermatol. 2020. Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss. doi:10.4103/ijd.IJD_482_18 PubMed
- [9] Marialuisa Piccolo et al.. Nutrients. 2019. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. doi:10.3390/nu11123041 PubMed
- [10] Jessica Cervantes et al.. Skin Appendage Disord. 2018. Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature. doi:10.1159/000477671 PubMed
- [11] Gian Carlo Tenore et al.. J Med Food. 2018. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … doi:10.1089/jmf.2017.0016 PubMed
- [12] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [13] Suruchi Garg et al.. Stem Cell Investig. 2017. Platelet-rich plasma-an 'Elixir' for treatment of alopecia: personal experience on 117 patients with review of literature. doi:10.21037/sci.2017.06.07 PubMed
- [14] Christina Beer et al.. ScientificWorldJournal. 2014. A clinical trial to investigate the effect of Cynatine HNS on hair and nail parameters. doi:10.1155/2014/641723 PubMed
- [15] Petra Clara Arck et al.. Exp Dermatol. 2003. Topical minoxidil counteracts stress-induced hair growth inhibition in mice. doi:10.1034/j.1600-0625.2003.00028.x PubMed
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