What is the recommended dosage for Vitamin K?

General: 90-120 mcg/day (AI); Skin Health: 90-120 mcg/day (limited evidence for higher doses)

What are the side effects of Vitamin K?

Potential side effects include: Generally well-tolerated, Rare allergic reactions.

What is vitamin K and how may it relate to skin health?

Vitamin K plays roles in blood clotting and may support skin healing and reduce dark circles under the eyes by strengthening capillary walls. Topical vitamin K is used in some dermatological products for bruising and post-procedure recovery. Oral vitamin K supplementation for skin benefits has limited clinical evidence.

What dosage of vitamin K has been studied for skin conditions?

Most skin-related vitamin K research involves topical application rather than oral supplementation. Topical studies have used 1–5% vitamin K1 (phylloquinone) creams for bruising and dark circles. The RDA for oral vitamin K is 90–120 mcg. Vitamin K2 supplementation at 90–180 mcg daily is studied primarily for bone and cardiovascular health.

What are the potential side effects of vitamin K supplements?

Vitamin K1 and K2 are generally safe at supplemental doses. The critical interaction is with warfarin and other vitamin K antagonist anticoagulants, where vitamin K can reduce anticoagulant efficacy. Individuals on warfarin must maintain consistent vitamin K intake. No tolerable upper intake level has been established for vitamin K.

Vitamin K

other

Also known as: Phylloquinone (K1), Menaquinone (K2), Phytonadione, MK-4, MK-7

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About

Vitamin K is a fat-soluble vitamin essential for blood coagulation that may support skin healing and reduce bruising. Topical vitamin K has been studied for dark circles under the eyes. Oral supplementation for skin has minimal clinical evidence, though K2 is being investigated for elastic fiber calcification prevention.

How It Works

Fat-soluble vitamin essential for blood coagulation (carboxylation of clotting factors); may support skin healing and reduce bruising; vitamin K-dependent proteins (Gas6) are involved in skin cell proliferation; topical vitamin K may reduce dark circles by strengthening capillary walls.

Evidence For Conditions

Condition	Grade	Studies	Participants
Dark Circles Under Eyes	D	2	80	View →

Side Effects

Generally well-tolerated
Rare allergic reactions

Drug & Supplement Interactions

Warfarin and other anticoagulants (vitamin K directly antagonizes warfarin — maintain consistent intake)
Bile acid sequestrants (may reduce vitamin K absorption)
Orlistat (may reduce absorption of fat-soluble vitamins)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

N-Acetyl Cysteine Pantothenic Acid

Quick Facts

Dosage: General: 90-120 mcg/day (AI); Skin_Health: 90-120 mcg/day (limited evidence for higher doses)
Forms: capsule softgel tablet topical cream
Natural Sources: Dark leafy greens (kale, spinach), Natto, Fermented foods, Broccoli, Brussels sprouts
Upper Limit: No established UL for K1; K2 generally safe at studied doses
Best Time: With meals containing fat

Evidence Summary

Dark Circles Under Eyes D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.