What is the recommended dosage for Selenium?

General: 55 mcg/day (RDA); Skin Health: 55-200 mcg/day

What are the side effects of Selenium?

Potential side effects include: Garlic breath odor, Nail brittleness and loss (selenosis), Hair loss (at toxic doses), Gastrointestinal disturbances.

What is selenium and how may it support skin health?

Selenium is a trace mineral that functions through selenoproteins, including glutathione peroxidase, protecting skin cells from oxidative damage. Adequate selenium is important for UV protection and immune defense in skin. Some research suggests selenium may play a role in preventing certain skin cancers and supporting skin elasticity.

What dosage of selenium has been studied for skin benefits?

Clinical studies have used 100–200 mcg of selenium per day. The RDA is 55 mcg. The Nutritional Prevention of Cancer trial used 200 mcg of selenized yeast. Selenium status varies by geographic region; supplementation is most relevant for individuals in selenium-deficient areas. Brazil nuts are a very rich dietary source.

What are the potential side effects of selenium supplements?

Chronic selenium excess (selenosis) causes garlic breath, hair loss, nail brittleness, and fatigue. The tolerable upper intake level is 400 mcg daily. High selenium status has been associated with increased type 2 diabetes risk. In selenium-replete populations, supplementation may not provide additional skin benefits.

Selenium

mineral

Also known as: Selenomethionine, Selenium Yeast, Sodium Selenite, Selenocysteine

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About

Selenium is incorporated into selenoproteins (glutathione peroxidases, thioredoxin reductases) that protect skin cells from oxidative damage. The SU.VI.MAX trial found selenium-containing supplements may reduce skin cancer risk in men. The narrow therapeutic window (toxicity at > 400 mcg/day) requires careful dosing.

How It Works

Essential trace mineral incorporated into selenoproteins (glutathione peroxidases, thioredoxin reductases) that protect skin cells from oxidative damage; supports thyroid hormone metabolism affecting skin turnover; may modulate UV-induced inflammation and apoptosis.

Evidence For Conditions

Condition	Grade	Studies	Participants
UV Protection (Internal Photoprotection)	C	5	1800	View →

Side Effects

Garlic breath odor
Nail brittleness and loss (selenosis)
Hair loss (at toxic doses)
Gastrointestinal disturbances

Drug & Supplement Interactions

Cisplatin and other chemotherapy (may reduce drug efficacy)
Statins (may affect selenium status)
Blood thinners (theoretical interaction)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Copper Silicon (Silica) Zinc

Quick Facts

Dosage: General: 55 mcg/day (RDA); Skin_Health: 55-200 mcg/day
Forms: capsule tablet liquid
Natural Sources: Brazil nuts (1-2 provide daily needs), Seafood, Organ meats, Whole grains, Eggs
Upper Limit: 400 mcg/day (toxicity: selenosis)
Best Time: With meals

Evidence Summary

UV Protection (Internal Photoprotection) C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.