What is the recommended dosage for Resveratrol?

General: 150-500 mg/day; Skin Health: 250-500 mg/day trans-resveratrol

What are the side effects of Resveratrol?

Potential side effects include: Gastrointestinal discomfort at high doses, Diarrhea, May affect platelet aggregation.

What is resveratrol and how may it support skin health?

Resveratrol is a polyphenol found in grape skins and red wine with antioxidant and anti-inflammatory properties. It activates sirtuins (SIRT1) involved in cellular repair and longevity pathways. Some clinical studies suggest oral resveratrol may improve skin hydration, elasticity, and reduce hyperpigmentation.

What dosage of resveratrol has been studied for skin benefits?

Skin-related studies have used 25–250 mg of resveratrol per day for 4–12 weeks. Due to low oral bioavailability, higher doses or enhanced formulations may be needed. Trans-resveratrol is the more biologically active isomer. Studies often combined resveratrol with other antioxidants.

What are the potential side effects of resveratrol?

Common side effects include gastrointestinal discomfort, nausea, and diarrhea at higher doses. Resveratrol may have estrogenic activity. It can interact with blood thinners and drugs metabolized by CYP enzymes. Long-term safety at supplemental doses is not well established in humans.

Resveratrol

antioxidant

Also known as: trans-Resveratrol, 3,5,4'-Trihydroxystilbene

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About

Resveratrol is a polyphenol stilbene that activates SIRT1 longevity pathways and inhibits tyrosinase to reduce melanogenesis. In vitro evidence is strong, but oral bioavailability is extremely low (< 2%). A small RCT found 250 mg/day for 60 days improved skin smoothness and reduced hyperpigmentation.

How It Works

Polyphenol stilbene that activates SIRT1 (sirtuin 1) longevity pathways; inhibits tyrosinase to reduce melanogenesis; suppresses NF-kB and COX-2 inflammatory cascades; may protect against UV-induced DNA damage and MMP expression.

Evidence For Conditions

Condition	Grade	Studies	Participants
Aging Skin & Wrinkles	C	4	200	View →

Side Effects

Gastrointestinal discomfort at high doses
Diarrhea
May affect platelet aggregation

Drug & Supplement Interactions

Anticoagulants (may have antiplatelet effects)
CYP450 substrates (may inhibit drug metabolism)
Estrogen-sensitive conditions (has weak estrogenic activity)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Alpha-Lipoic Acid Astaxanthin CoQ10 Glutathione

Quick Facts

Dosage: General: 150-500 mg/day; Skin_Health: 250-500 mg/day trans-resveratrol
Forms: capsule tablet liquid powder
Natural Sources: Red grapes, Red wine, Peanuts, Blueberries, Cranberries, Japanese knotweed (Polygonum cuspidatum)
Upper Limit: Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day
Best Time: With meals for improved absorption; low oral bioavailability (~1-2%)

Evidence Summary

Aging Skin & Wrinkles C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.