What is the recommended dosage for Biotin?

General: 30 mcg/day (AI); Skin Hair Nails: 2,500-5,000 mcg/day

What are the side effects of Biotin?

Potential side effects include: Generally well-tolerated, May cause acne breakouts at high doses (> 5,000 mcg), Interferes with troponin and thyroid laboratory tests.

What is biotin and how may it support skin, hair, and nail health?

Biotin (vitamin B7) is a water-soluble B vitamin involved in fatty acid synthesis and amino acid metabolism relevant to skin health. While biotin is widely marketed for hair, skin, and nails, clinical evidence for benefits in non-deficient individuals is limited. Biotin supplementation primarily benefits those with documented deficiency.

What dosage of biotin has been studied for skin and hair?

Studies have used 2,500–10,000 mcg of biotin per day, far exceeding the adequate intake of 30 mcg. Most positive results come from case reports or studies in individuals with brittle nail syndrome. The evidence for hair growth in non-deficient individuals is weak. Typical supplemental doses are 2,500–5,000 mcg daily.

What are the potential side effects of biotin supplements?

Biotin is generally well tolerated, but high doses can interfere with numerous laboratory tests (troponin, thyroid hormones, hormone levels, vitamin D), potentially leading to misdiagnosis. The FDA issued a safety communication about this in 2017. Inform your healthcare provider about biotin supplementation before blood tests. High-dose biotin may worsen acne in some individuals.

Biotin

vitamin

Also known as: Vitamin B7, Vitamin H, Coenzyme R

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About

Biotin (vitamin B7) is a water-soluble B-vitamin serving as a cofactor for carboxylase enzymes essential for fatty acid synthesis and amino acid metabolism. Biotin deficiency clearly causes dermatitis, brittle nails, and hair loss. However, systematic reviews have found limited evidence that supplementation above adequate intake levels improves skin health in non-deficient individuals.

How It Works

Water-soluble B-vitamin (B7) serving as a cofactor for carboxylase enzymes essential for fatty acid synthesis and amino acid metabolism; supports keratin infrastructure in skin, hair, and nails through lipid metabolism in the stratum corneum.

Evidence For Conditions

Condition	Grade	Studies	Participants
Hair, Skin & Nails Health	C	8	540	View →
Dry Skin	D	2	100	View →

Side Effects

Generally well-tolerated
May cause acne breakouts at high doses (> 5,000 mcg)
Interferes with troponin and thyroid laboratory tests

Drug & Supplement Interactions

Laboratory test interference (troponin, thyroid panels, vitamin D assays)
Anticonvulsants (carbamazepine, phenytoin may reduce biotin levels)
Prolonged antibiotic use (may reduce gut biotin synthesis)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Niacinamide Vitamin A (Retinol) Vitamin C Vitamin D Vitamin E

Quick Facts

Dosage: General: 30 mcg/day (AI); Skin_Hair_Nails: 2,500-5,000 mcg/day
Forms: capsule tablet gummy liquid
Natural Sources: Eggs, Nuts, Seeds, Liver, Sweet potatoes, Salmon, Avocado
Upper Limit: No established UL (water-soluble); may interfere with lab tests at high doses
Best Time: With meals for better absorption

Evidence Summary

Hair, Skin & Nails Health C

Dry Skin D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.