What is the recommended dosage for Glutathione?

General: 250-1,000 mg/day; Skin Lightening: 500-1,000 mg/day

What are the side effects of Glutathione?

Potential side effects include: Generally well-tolerated, Mild bloating or gastrointestinal discomfort, Rare skin rash.

What is glutathione and how may it support skin health?

Glutathione is the body's master antioxidant, playing roles in detoxification and melanin regulation. It shifts melanin production toward lighter pheomelanin rather than darker eumelanin. Clinical trials, particularly from East Asia, show oral and sublingual glutathione may reduce melanin index and improve skin brightness.

What dosage of glutathione has been studied for skin lightening?

Clinical trials have used 250–500 mg of oral glutathione per day for 4–12 weeks. Both reduced (GSH) and oxidized (GSSG) forms have been studied. A Thai RCT showed significant skin lightening with 500 mg GSH daily for 12 weeks. Liposomal and sublingual forms may improve bioavailability.

What are the potential side effects of glutathione supplements?

Oral glutathione is generally well tolerated. Mild side effects include bloating and abdominal discomfort. Long-term safety at supplemental doses is not well established. IV glutathione (used off-label for skin lightening in some countries) carries additional risks and is not FDA-approved for this purpose. Zinc supplementation may support endogenous glutathione.

Glutathione
Glutathione

antioxidant

Aussi connu sous le nom de: GSH, Reduced Glutathione, L-Glutathione, Liposomal Glutathione, S-Acetyl Glutathione

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'skincited.com'; const params = 'ingredient\u003Dglutathione'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

About

Glutathione is a tripeptide (glutamate-cysteine-glycine) serving as the body's master antioxidant. It inhibits tyrosinase and shifts melanogenesis from eumelanin (dark) to pheomelanin (light). A 2023 systematic review found oral glutathione (250-1,000 mg/day) may reduce melanin index in multiple RCTs, primarily in Asian populations.

How It Works

Tripeptide (glutamate-cysteine-glycine) serving as the body's master antioxidant; inhibits tyrosinase and shifts melanogenesis from eumelanin (dark) to pheomelanin (light); detoxifies reactive oxygen species and supports vitamin C and E recycling.

Evidence For Conditions

Pathologie	Note	Études	Participants
Hyperpigmentation	C	6	350	Voir →

Side Effects

Generally well-tolerated
Mild bloating or gastrointestinal discomfort
Rare skin rash

Drug & Supplement Interactions

Chemotherapy agents (may interfere — consult oncologist)
Acetaminophen (glutathione is involved in its detoxification)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Astaxanthin Resveratrol CoQ10 Alpha-Lipoic Acid

En bref

Posologie: General: 250-1,000 mg/day; Skin_Lightening: 500-1,000 mg/day
Formes: capsule sublingual liposomal liquid IV (clinical setting)
Sources naturelles: Asparagus, Avocado, Spinach, Okra, Cruciferous vegetables, Garlic
Limite supérieure: Not established; generally well-tolerated up to 1,000 mg/day
Meilleur moment: On an empty stomach for better absorption; liposomal forms have improved bioavailability

Synthèse des preuves

Hyperpigmentation C

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.