What is the recommended dosage for Pantothenic Acid?

General: 5 mg/day (AI); Acne Skin Health: 500-2,000 mg/day (high-dose protocol)

What are the side effects of Pantothenic Acid?

Potential side effects include: Diarrhea at very high doses, Mild gastrointestinal discomfort.

What is pantothenic acid and how may it support skin health?

Pantothenic acid (vitamin B5) is involved in coenzyme A synthesis, which is critical for fatty acid metabolism and skin barrier lipid production. It is widely used in topical skincare as dexpanthenol. Some clinical evidence suggests high-dose oral pantothenic acid may reduce acne lesions, possibly through improved lipid metabolism.

What dosage of pantothenic acid has been studied for acne?

An RCT found that a pantothenic acid-based supplement at an equivalent of approximately 2,200 mg B5 per day significantly reduced acne lesions after 12 weeks. Earlier observational studies used much higher doses (up to 10 grams daily), which are not recommended. The Adequate Intake is only 5 mg for adults.

What are the potential side effects of pantothenic acid supplements?

Pantothenic acid is generally well tolerated at moderate supplemental doses. Very high doses (above 10 grams daily) may cause diarrhea and gastrointestinal distress. No tolerable upper intake level has been established. At studied acne doses (2–5 grams), mild digestive discomfort has been reported. Topical dexpanthenol is very well tolerated.

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Pantothenic Acid

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يُعرف أيضاً بـ: Vitamin B5, Calcium D-Pantothenate, Dexpanthenol (topical), D-Pantothenic Acid

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Pantothenic acid is a precursor to coenzyme A (CoA), essential for fatty acid synthesis. A randomized double-blind trial found high-dose pantothenic acid (2,200 mg/day for 12 weeks) significantly reduced total facial acne lesions by 68.2%. The high doses required are considerably above the AI (5 mg/day).

How It Works

Precursor to coenzyme A (CoA), essential for fatty acid synthesis and metabolism; supports skin barrier lipid production; high-dose supplementation may redirect CoA toward fatty acid oxidation in sebaceous glands, potentially reducing sebum production and acne.

Evidence For Conditions

الحالة	التقييم	الدراسات	المشاركون
Acne	C	3	200	عرض →

Side Effects

Diarrhea at very high doses
Mild gastrointestinal discomfort

Drug & Supplement Interactions

No significant drug interactions documented at typical doses
May enhance acetylcholine production (theoretical interaction with cholinergic drugs)

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Related Ingredients

Vitamin K N-Acetyl Cysteine

حقائق سريعة

الجرعة: General: 5 mg/day (AI); Acne_Skin_Health: 500-2,000 mg/day (high-dose protocol)
الأشكال الدوائية: capsule tablet powder topical (dexpanthenol)
المصادر الطبيعية: Liver, Chicken, Sunflower seeds, Mushrooms, Avocado, Yogurt, Whole grains
الحد الأعلى: Not established; high doses (10,000+ mg/day) may cause GI distress
أفضل وقت: With meals; split doses recommended for high amounts

ملخص الأدلة

Acne C

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