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SkinCited

Nicotinamide
Nicotinamide

specialty

别名: Nicotinamide (high-dose oral), Vitamin B3 (oral oncology dose)

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About





            

                
Nicotinamide at chemoprevention doses replenishes cellular NAD+ depleted by UV-induced PARP activation, enhancing cellular energy for DNA repair. The landmark ONTRAC trial (386 patients, NEJM 2015) found nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals.

            

        

        

        
        
        

            

  
How It Works





            

                
Amide form of vitamin B3 (distinct from niacinamide in dosing context); replenishes cellular NAD+ depleted by UV-induced PARP activation; enhances cellular energy for DNA repair; supports immune surveillance of skin cancer precursors; strengthens skin barrier ceramide synthesis.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        UV Protection (Internal Photoprotection)
                                    
                                
                                
                                    A

                                
                                
                                    5
                                
                                
                                    686
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally well-tolerated (no flushing)
                
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                    Mild gastrointestinal discomfort at high doses
                
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                    Rare hepatotoxicity at very high doses
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticonvulsants (carbamazepine — may increase levels)
                
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                    Isoniazid (competes for NAD+ pathways)
                
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                    Hepatotoxic drugs (potential additive liver effect at high doses)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Pine Bark Extract (Pycnogenol)
                    
                
                
                
                    Polypodium leucotomos
                    
                
                
                
                    MSM
                    
                
                
            

        

        
    


    
    












    

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