What is the recommended dosage for N-Acetyl Cysteine?

General: 600-1,200 mg/day; Skin Health: 600-1,800 mg/day

What are the side effects of N-Acetyl Cysteine?

Potential side effects include: Nausea and vomiting, Diarrhea, Unpleasant sulfur smell, Rare: bronchospasm (in asthmatics).

What is N-acetyl cysteine (NAC) and how may it support skin health?

NAC is a precursor to glutathione, the body's primary intracellular antioxidant. It may support skin health through glutathione-mediated antioxidant defense, melanin modulation, and anti-inflammatory effects. NAC has been studied for acne (as an adjunct), wound healing, and as a mucolytic agent with potential skin benefits through improved detoxification.

What dosage of NAC has been studied for skin benefits?

Clinical studies have used 600–1,800 mg of NAC per day for various indications. Skin-specific studies are limited, but dermatological applications have used 600–1,200 mg daily. For glutathione support, 600 mg twice daily is commonly used. NAC's primary evidence base is for respiratory and liver conditions rather than skin specifically.

What are the potential side effects of NAC supplements?

Common side effects include nausea, vomiting, diarrhea, and a sulfurous odor or taste. NAC may interact with nitroglycerin (enhancing hypotensive effects) and activated charcoal (reducing its efficacy). The FDA has raised questions about NAC's status as a dietary supplement. Very high doses may act as a pro-oxidant.

N-Acetyl Cysteine
N-Acetyl Cysteine

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Также известен как: NAC, N-Acetylcysteine, Acetylcysteine

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About

NAC is a precursor to glutathione that provides cysteine for glutathione synthesis and directly scavenges reactive oxygen species. A controlled trial found NAC (1,200 mg/day) reduced melanin index. NAC is sometimes used as an alternative to direct glutathione supplementation, which has questionable oral bioavailability.

How It Works

Precursor to glutathione (the body's master antioxidant); provides cysteine for glutathione synthesis; directly scavenges reactive oxygen species; mucolytic properties; may modulate NF-kB signaling and reduce inflammatory mediators implicated in acne, eczema, and skin aging.

Evidence For Conditions

Состояние	Оценка	Исследования	Участники
Hyperpigmentation	C	3	150	Подробнее →

Side Effects

Nausea and vomiting
Diarrhea
Unpleasant sulfur smell
Rare: bronchospasm (in asthmatics)

Drug & Supplement Interactions

Nitroglycerin (may enhance vasodilatory effects)
Activated charcoal (reduces NAC absorption)
Anticoagulants (may have mild antiplatelet effects)

Всегда сообщайте лечащему врачу обо всех принимаемых добавках.

Related Ingredients

Vitamin K Pantothenic Acid

Основные факты

Дозировка: General: 600-1,200 mg/day; Skin_Health: 600-1,800 mg/day
Формы выпуска: capsule tablet effervescent powder
Природные источники: Not naturally occurring; cysteine found in poultry, yogurt, eggs, garlic, onions, cruciferous vegetables
Верхний предел: Generally well-tolerated up to 2,400 mg/day
Лучшее время приёма: On an empty stomach for better absorption; or with meals if GI sensitivity

Обзор доказательной базы

Hyperpigmentation C

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.