症状・状態

18 エビデンスに基づいたサプリメント研究のある健康状態

Explore health conditions with evidence-graded supplement recommendations. Each condition page ranks ingredients by the strength of clinical research supporting them.

How We Grade Evidence

各症状ページでは、臨床エビデンスの強さに基づいてサプリメント成分をランク付けしています。各グレードの意味は以下の通りです：

Strong Evidence

Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.

Good Evidence

At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.

Some Evidence

Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.

Very Early Research

In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.

Acne

Affects approximately 85% of people aged 12-24; 12-22% of adult women experience acne

Comedones (blackheads, whiteheads) Papules and pustules Nodules and cysts (severe) +3

Eczema (Atopic Dermatitis)

Affects 15-20% of children and 1-3% of adults worldwide

Intense itching (pruritus) Dry and scaly skin Red or inflamed patches +3

Psoriasis

Affects 2-3% of the global population; plaque psoriasis accounts for 80-90% of cases

Thick red plaques with silvery-white scales Itching and burning Nail changes (pitting, onycholysis) +2

Aging Skin & Wrinkles

Universal process; visible signs typically begin in late 20s to early 30s

Fine lines and wrinkles Loss of skin elasticity and firmness Thinning skin +4

Hyperpigmentation

Melasma affects 15-50% of pregnant women; PIH common in darker skin tones (Fitzpatrick IV-VI)

Dark patches on face (melasma: cheeks, forehead, upper lip) Dark spots at sites of prior acne or injury (PIH) Age spots (solar lentigines) +1

Dry Skin

Affects approximately 29-85% of adults depending on climate, age, and definition used

Tight or rough skin texture Visible flaking or peeling Itching +3

Sun Damage & Photoaging

Virtually universal in adults with cumulative sun exposure; responsible for up to 90% of visible skin aging

Solar lentigines (sun spots) Deep wrinkles and leathery texture Solar elastosis +3

Rosacea

Affects 2-10% of the global population; more common in fair-skinned individuals

Persistent central facial erythema Flushing and blushing episodes Papules and pustules (without comedones) +3

Hair, Skin & Nails Health

One of the most popular supplement categories; hair/skin/nail supplement market exceeds $2 billion annually

Brittle nails Dull or thinning hair Dry or lackluster skin +3

Skin Barrier Function

Impaired in multiple conditions: eczema, psoriasis, rosacea, aged skin, sensitive skin

Increased transepidermal water loss (TEWL) Sensitivity to irritants Stinging or burning with products +3

Collagen Loss

Universal age-related process; accelerated in post-menopausal women

Loss of skin firmness and elasticity Increased wrinkle formation Skin thinning +3

UV Protection (Internal Photoprotection)

Relevant to all individuals with sun exposure; growing consumer interest

Sunburn susceptibility Premature photoaging Actinic keratoses +2

Wound Healing

Relevant to all individuals; chronic non-healing wounds affect 1-2% of the population in developed countries

Delayed wound closure Excessive scar formation Wound infection +2

Dark Circles Under Eyes

Extremely common; a primary cosmetic complaint across all age groups and ethnicities

Dark discoloration under eyes Bluish or purplish tint (vascular) Brown pigmentation (melanin) +2

Stretch Marks

Affects 50-90% of pregnant women; common during adolescent growth spurts and rapid weight changes

Linear streaks on skin Initially red/purple (striae rubrae) Mature to white/silvery (striae albae) +2

Cellulite

Affects 80-90% of post-pubertal women; rare in men due to different connective tissue architecture

Dimpled or lumpy skin (orange-peel texture) Primarily on thighs, buttocks, and hips May worsen with age and weight gain +1

Keratosis Pilaris

Affects 50-80% of adolescents and approximately 40% of adults

Small rough bumps on upper arms, thighs, cheeks, or buttocks Dry or sandpaper-like skin texture Mild redness around bumps +1

Vitiligo

Affects 0.5-2% of the global population

Well-defined white patches on skin Premature graying of hair Loss of color in oral mucosa +2

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。