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Polypodium leucotomos
Polypodium leucotomos

specialty

Noto anche come: PLE, Fernblock, Heliocare, Calaguala, Anapsos

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About





            

                
Polypodium leucotomos is a tropical fern extract that reduces UV-induced oxidative stress and DNA damage. A systematic review of 5 RCTs found oral PLE significantly increased the minimal erythema dose (MED) by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

            

        

        

        
        
        

            

  
How It Works





            

                
Tropical fern extract rich in phenolic compounds that reduce UV-induced oxidative stress; inhibits MMP-1 expression; suppresses UV-mediated COX-2 and AP-1 activation; reduces UV-induced DNA damage (cyclobutane pyrimidine dimers); may modulate Langerhans cell depletion from UV exposure.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                Condizione
                                Grado
                                Studi
                                Partecipanti
                                
                            

                        
                        
                            
                            

                                
                                    
                                        UV Protection (Internal Photoprotection)
                                    
                                
                                
                                    B

                                
                                
                                    5
                                
                                
                                    250
                                
                                
                                    
                                        Visualizza →
                                    
                                
                            

                            
                            

                                
                                    
                                        Hyperpigmentation
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    150
                                
                                
                                    
                                        Visualizza →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally well-tolerated
                
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                    Mild gastrointestinal discomfort (rare)
                
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                    Pruritus (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Immunosuppressants (may modulate immune function)
                
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                    Photosensitizing medications (may modulate UV response)
                
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                Informare sempre il proprio medico di tutti gli integratori che si assumono.Informate sempre il vostro medico di tutti gli integratori che assumete.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Pine Bark Extract (Pycnogenol)
                    
                
                
                
                    Nicotinamide
                    
                
                
                
                    MSM
                    
                
                
            

        

        
    


    
    












    

        Avvertenza FDA:
        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.