What is the recommended dosage for Vitamin E?

General: 15 mg (22.4 IU)/day (RDA); Skin Health: 15-400 IU/day

What are the side effects of Vitamin E?

Potential side effects include: Generally well-tolerated at recommended doses, Increased bleeding risk at high doses (> 400 IU/day), Nausea and diarrhea (rare).

What is vitamin E and how may it support skin health?

Vitamin E is a fat-soluble antioxidant that protects cell membranes from oxidative damage, including UV-induced lipid peroxidation in skin. When combined with vitamin C, oral vitamin E has shown synergistic photoprotective effects. It may also support skin barrier function and wound healing.

What dosage of vitamin E has been studied for skin outcomes?

Skin-related studies have used 400–1,000 IU of vitamin E (alpha-tocopherol) per day, often combined with vitamin C. The RDA is 15 mg (22.4 IU). Photoprotection studies typically combined 1,000 IU vitamin E with 2,000 mg vitamin C. The mixed tocopherol form may be more beneficial than alpha-tocopherol alone.

What are the potential side effects of vitamin E supplements?

High-dose vitamin E (above 400 IU daily) has been associated with increased bleeding risk and possibly increased all-cause mortality. It may interact with blood thinners and antiplatelet drugs. Topical vitamin E can cause contact dermatitis in some individuals. The tolerable upper intake level is 1,000 mg (1,500 IU natural form).

Vitamin E

vitamin

Also known as: Alpha-Tocopherol, d-Alpha-Tocopherol, Tocopheryl Acetate, Mixed Tocopherols

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About

Vitamin E is the major lipid-soluble antioxidant in human skin, concentrated in the stratum corneum. It accumulates in cell membranes and protects polyunsaturated fatty acids from lipid peroxidation. Research suggests vitamin E works synergistically with vitamin C for photoprotection, and combined oral supplementation is associated with reduced sunburn response (higher MED).

How It Works

Fat-soluble antioxidant that accumulates in cell membranes and protects polyunsaturated fatty acids from lipid peroxidation; supports skin barrier function by maintaining stratum corneum lipid integrity; works synergistically with vitamin C to regenerate oxidized tocopherols.

Evidence For Conditions

Condition	Grade	Studies	Participants
UV Protection (Internal Photoprotection)	C	8	600	View →
Aging Skin & Wrinkles	C	6	350	View →

Side Effects

Generally well-tolerated at recommended doses
Increased bleeding risk at high doses (> 400 IU/day)
Nausea and diarrhea (rare)

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
Statins and niacin (may reduce HDL-raising benefit)
Chemotherapy and radiation (antioxidant interference — consult oncologist)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Biotin Niacinamide Vitamin A (Retinol) Vitamin C Vitamin D

Quick Facts

Dosage: General: 15 mg (22.4 IU)/day (RDA); Skin_Health: 15-400 IU/day
Forms: softgel capsule liquid topical
Natural Sources: Almonds, Sunflower seeds, Wheat germ oil, Hazelnuts, Spinach, Avocado
Upper Limit: 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)
Best Time: With meals containing fat for better absorption

Evidence Summary

UV Protection (Internal Photoprotection) C

Aging Skin & Wrinkles C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.