What is the recommended dosage for Vitamin D?

General: 600-800 IU/day (RDA); Skin Health: 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)

What are the side effects of Vitamin D?

Potential side effects include: Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses).

What is vitamin D and how may it relate to skin health?

Vitamin D plays roles in skin cell growth, differentiation, and immune function in the skin. Vitamin D receptors are present in keratinocytes. Low vitamin D levels have been associated with several skin conditions including psoriasis, atopic dermatitis, and vitiligo. Vitamin D analogs are used topically in psoriasis treatment.

What dosage of vitamin D has been studied for skin conditions?

Clinical studies for skin conditions have used 1,000–4,000 IU of vitamin D3 per day. Psoriasis studies have used up to 35,000 IU daily under close medical supervision (risk of hypercalcemia). For general skin health, maintaining adequate blood levels (30–50 ng/mL of 25-OH-D) through standard supplementation is recommended.

What are the potential side effects of vitamin D supplements?

Vitamin D is safe at recommended doses but excessive intake causes hypercalcemia with symptoms including nausea, weakness, confusion, and kidney damage. The tolerable upper intake level is 4,000 IU daily for adults, though some experts support higher levels under monitoring. Vitamin D3 is preferred over D2 for supplementation.

Vitamin D

vitamin

Also known as: Cholecalciferol (D3), Ergocalciferol (D2), Calciferol, Sunshine Vitamin

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About

Vitamin D is a secosteroid hormone produced in skin via UVB exposure that regulates keratinocyte differentiation, supports antimicrobial peptide production (cathelicidin), modulates immune responses, and supports wound healing. A systematic review found vitamin D deficiency is significantly associated with increased severity of atopic dermatitis, psoriasis, and vitiligo.

How It Works

Secosteroid hormone produced in skin via UVB exposure; regulates keratinocyte differentiation, supports antimicrobial peptide (cathelicidin) production, modulates immune responses in skin, and supports wound healing through calcium-dependent signaling.

Evidence For Conditions

Condition	Grade	Studies	Participants
Psoriasis	B	16	2200	View →
Eczema (Atopic Dermatitis)	B	12	1800	View →
Vitiligo	D	4	300	View →

Side Effects

Generally well-tolerated at recommended doses
Hypercalcemia at very high doses (nausea, vomiting, weakness)
Kidney stones (rare, at excessive doses)

Drug & Supplement Interactions

Thiazide diuretics (may increase calcium levels)
Corticosteroids (may reduce vitamin D absorption)
Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
Calcipotriene (additive vitamin D effect)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Biotin Niacinamide Vitamin A (Retinol) Vitamin C Vitamin E

Quick Facts

Dosage: General: 600-800 IU/day (RDA); Skin_Health: 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)
Forms: softgel capsule liquid drops gummy tablet
Natural Sources: Sunlight (UVB radiation), Fatty fish, Egg yolks, Fortified milk, Mushrooms (UV-exposed)
Upper Limit: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
Best Time: With meals containing fat for better absorption

Evidence Summary

Psoriasis B

Eczema (Atopic Dermatitis) B

Vitiligo D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.