What is the recommended dosage for Polypodium leucotomos?

General: 240-480 mg/day; Photoprotection: 480 mg/day (240 mg twice daily, 30-60 min before sun exposure)

What are the side effects of Polypodium leucotomos?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort (rare), Pruritus (rare).

What is Polypodium leucotomos and how may it support skin health?

Polypodium leucotomos extract (PLE, Fernblock) is derived from a tropical fern with demonstrated photoprotective properties. Multiple RCTs show oral PLE reduces UV-induced skin damage, erythema, and DNA damage. It is used as a systemic photoprotection supplement and has been studied for preventing polymorphic light eruption and melasma.

What dosage of Polypodium leucotomos has been studied for sun protection?

Clinical studies have used 240–480 mg of PLE per day, typically taken 30 minutes before sun exposure. A common dose is 240 mg twice daily. Studies show PLE increases the minimal erythema dose (MED) by approximately 2–3 fold, providing supplemental UV protection. It does not replace topical sunscreen.

What are the potential side effects of Polypodium leucotomos?

PLE is generally well tolerated in clinical trials with no significant adverse events reported. Mild gastrointestinal discomfort has been noted. It should not be used as a substitute for sunscreen or sun-protective clothing. Individuals with fern allergies should exercise caution. Long-term safety data beyond 6 months is limited.

Polypodium leucotomos

specialty

Also known as: PLE, Fernblock, Heliocare, Calaguala, Anapsos

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About

Polypodium leucotomos is a tropical fern extract that reduces UV-induced oxidative stress and DNA damage. A systematic review of 5 RCTs found oral PLE significantly increased the minimal erythema dose (MED) by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

How It Works

Tropical fern extract rich in phenolic compounds that reduce UV-induced oxidative stress; inhibits MMP-1 expression; suppresses UV-mediated COX-2 and AP-1 activation; reduces UV-induced DNA damage (cyclobutane pyrimidine dimers); may modulate Langerhans cell depletion from UV exposure.

Evidence For Conditions

Condition	Grade	Studies	Participants
UV Protection (Internal Photoprotection)	B	5	250	View →
Hyperpigmentation	C	3	150	View →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort (rare)
Pruritus (rare)

Drug & Supplement Interactions

Immunosuppressants (may modulate immune function)
Photosensitizing medications (may modulate UV response)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

MSM Nicotinamide Pine Bark Extract (Pycnogenol)

Quick Facts

Dosage: General: 240-480 mg/day; Photoprotection: 480 mg/day (240 mg twice daily, 30-60 min before sun exposure)
Forms: capsule tablet
Natural Sources: Polypodium leucotomos fern (Central and South American tropical fern)
Upper Limit: Generally well-tolerated up to 960 mg/day
Best Time: 30-60 minutes before sun exposure; can also be taken daily for baseline protection

Evidence Summary

UV Protection (Internal Photoprotection) B

Hyperpigmentation C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.