Omega-3 Fatty Acids
fatty_acidAlso known as: Fish Oil, EPA, DHA, Marine Omega-3, Eicosapentaenoic Acid, Docosahexaenoic Acid
About
EPA and DHA are incorporated into skin cell membranes, modulating inflammatory eicosanoid production and competing with pro-inflammatory omega-6 arachidonic acid. A systematic review found omega-3 supplementation (1-4 g/day) reduced UV-induced erythema and may increase the skin's minimal erythema dose (MED). In atopic dermatitis, a meta-analysis suggested modest improvements in clinical severity scores.
How It Works
EPA and DHA are incorporated into skin cell membranes, modulating inflammatory eicosanoid production; compete with pro-inflammatory omega-6 arachidonic acid for COX and LOX enzyme pathways; support skin barrier lipid composition and may increase the minimal erythema dose (MED) for UV protection.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Eczema (Atopic Dermatitis) | B | 14 | 1200 | View → |
| UV Protection (Internal Photoprotection) | B | 8 | 400 | View → |
| Acne | C | 5 | 300 | View → |
| Rosacea | C | 3 | 180 | View → |
| Psoriasis | D | 6 | 400 | View → |
Side Effects
- Fishy aftertaste or burping
- Mild gastrointestinal discomfort
- Potential increased bleeding time at very high doses
- May lower blood pressure slightly
Drug & Supplement Interactions
- Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- Blood pressure medications (additive hypotensive effect)
- Orlistat (may reduce omega-3 absorption)
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.