What is the recommended dosage for Niacinamide?

General: 14-16 mg/day NE (RDA); Skin Health: 500-1,500 mg/day oral nicotinamide

What are the side effects of Niacinamide?

Potential side effects include: Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day).

What is niacinamide and how may it support skin health?

Niacinamide (nicotinamide, vitamin B3) is well-studied for skin benefits both topically and orally. It supports the skin barrier by increasing ceramide production, has anti-inflammatory effects, and may reduce melanin transfer to keratinocytes. A landmark RCT showed oral nicotinamide reduced non-melanoma skin cancer rates by 23%.

What dosage of niacinamide has been studied for skin benefits?

The skin cancer prevention trial used 500 mg of oral nicotinamide twice daily (1,000 mg/day). For skin barrier and anti-inflammatory effects, topical studies typically use 2–5% concentrations. Oral supplementation at 500–1,500 mg daily has been studied for acne and rosacea with some positive results.

What are the potential side effects of niacinamide supplements?

Niacinamide is generally well tolerated and does not cause the flushing associated with niacin (nicotinic acid). Mild gastrointestinal effects may occur at higher doses. Very high doses (above 3,000 mg daily) may cause liver toxicity. Niacinamide does not significantly affect lipid profiles, unlike niacin.

Niacinamide

vitamin

Also known as: Nicotinamide, Vitamin B3, Niacin amide

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About

Niacinamide is the amide form of vitamin B3 that supports NAD+/NADH coenzyme production, strengthens the epidermal lipid barrier by stimulating ceramide and fatty acid synthesis, and inhibits melanosome transfer from melanocytes to keratinocytes. The landmark ONTRAC trial found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% in high-risk individuals.

How It Works

Amide form of vitamin B3 that supports NAD+/NADH coenzyme production; strengthens the epidermal lipid barrier by stimulating ceramide and fatty acid synthesis; inhibits melanosome transfer from melanocytes to keratinocytes (reducing hyperpigmentation); suppresses NF-kB-mediated inflammatory pathways in skin.

Evidence For Conditions

Condition	Grade	Studies	Participants
Acne	A	15	1200	View →
UV Protection (Internal Photoprotection)	A	5	686	View →

Side Effects

Generally well-tolerated (no flushing unlike niacin)
Mild gastrointestinal discomfort at high doses
Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Drug & Supplement Interactions

Anticonvulsants (carbamazepine — may increase niacinamide levels)
Hepatotoxic drugs (potential additive liver effect at high doses)
Isoniazid (competes for NAD+ pathways)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Biotin Vitamin A (Retinol) Vitamin C Vitamin D Vitamin E

Quick Facts

Dosage: General: 14-16 mg/day NE (RDA); Skin_Health: 500-1,500 mg/day oral nicotinamide
Forms: capsule tablet topical
Natural Sources: Poultry, Fish, Mushrooms, Green peas, Fortified cereals, Peanuts
Upper Limit: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
Best Time: With meals; can be split into 2-3 doses

Evidence Summary

Acne A

UV Protection (Internal Photoprotection) A

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.