What is the recommended dosage for Hyaluronic Acid?

General: 120-240 mg/day; Skin Hydration: 120-200 mg/day

What are the side effects of Hyaluronic Acid?

Potential side effects include: Generally well-tolerated, Rare mild gastrointestinal discomfort.

What is hyaluronic acid and how may it support skin health?

Hyaluronic acid (HA) is a glycosaminoglycan naturally found in skin that holds up to 1,000 times its weight in water. Oral HA supplementation has been studied for skin hydration, and several RCTs show improvements in skin moisture content. HA levels in skin decrease with age, contributing to dryness and wrinkle formation.

What dosage of oral hyaluronic acid has been studied for skin?

Clinical trials have used 120–240 mg of oral hyaluronic acid per day. Both high and low molecular weight forms have been studied, with low molecular weight HA (below 300 kDa) showing better absorption in some studies. Improvements in skin hydration have been observed after 4–8 weeks of supplementation.

What are the potential side effects of oral hyaluronic acid?

Oral hyaluronic acid is generally well tolerated at studied doses. Mild gastrointestinal discomfort has been reported rarely. Theoretical concerns about HA promoting cancer growth exist from in vitro studies, but clinical evidence in humans is lacking. Individuals with a history of cancer should consult their healthcare provider.

Hyaluronic Acid

collagen_protein

Also known as: Hyaluronan, Sodium Hyaluronate, HA

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'skincited.com'; const params = 'ingredient\u003Dhyaluronic\u002Dacid'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

About

Hyaluronic acid is a glycosaminoglycan that retains up to 1,000x its weight in water, supporting dermal hydration. Oral supplementation increases circulating hyaluronic acid fragments that may stimulate fibroblast HA synthesis and upregulate moisture-retention in the stratum corneum. A 2017 meta-analysis found oral HA (120-240 mg/day) significantly improved skin moisture and reduced transepidermal water loss.

How It Works

Glycosaminoglycan that retains up to 1,000x its weight in water, supporting dermal hydration; oral supplementation increases circulating hyaluronic acid fragments that may stimulate fibroblast HA synthesis and upregulate moisture-retention in the stratum corneum.

Evidence For Conditions

Condition	Grade	Studies	Participants
Dry Skin	B	10	620	View →
Aging Skin & Wrinkles	B	8	480	View →
Skin Barrier Function	D	3	180	View →

Side Effects

Generally well-tolerated
Rare mild gastrointestinal discomfort

Drug & Supplement Interactions

No significant drug interactions documented

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Collagen Peptides Elastin Keratin

Quick Facts

Dosage: General: 120-240 mg/day; Skin_Hydration: 120-200 mg/day
Forms: capsule tablet liquid powder
Natural Sources: Bone broth, Soy-based foods, Root vegetables, Citrus fruits (supports endogenous production)
Upper Limit: Not established; well-tolerated up to 200 mg/day in trials lasting 12 months
Best Time: With meals for better absorption

Evidence Summary

Dry Skin B

Aging Skin & Wrinkles B

Skin Barrier Function D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.