Keratin untuk Hair, Skin & Nails Health
D Penelitian Hanya penelitian awal yang ada (studi laboratorium, laporan kasus).Limited evidence from small RCTs suggests solubilized keratin (500 mg/day) may improve skin moisture and elasticity, but most studies use proprietary extracts.
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D
Kesimpulan
Limited evidence from small RCTs suggests solubilized keratin (500 mg/day) may improve skin moisture and elasticity, but most studies use proprietary extracts.
Key Study Findings
Other
TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis.
Dose: None
vs: untreated controls
Outcome: hair follicle transition from telogen to anagen phase
Efek: None
None
Populasi: female and male rats, naturally aged and DHT-induced alopecia model mice
review
Nail Supplements: When, How, and Why?
Dose: biotin, collagen peptides, solubilized keratin MSM, choline-stabilized orthosilicic acid
vs: Placebo
Efek: None
None
in vitro/ex vivo study
A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond …
Dose: USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu
vs: Placebo
Efek: USPlus DERM IC50=0.39 μg/mL (vs 29.1 μg/mL standard extract); 0.4 μg/mL significantly reduced melani
None
Other
AP collagen peptides (APCPs) promote hair growth by activating the GSK-3β/β-catenin pathway and improve hair …
Dose: None
vs: None
Outcome: Hair growth
Efek: None
None
Populasi: Mouse model
Review
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Dose: None
vs: None
Outcome: Hair regrowth
Efek: None
None
Populasi: Alopecia patients
Case-control
n=60
Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss.
Dose: None
vs: Placebo
Efek: OR=12.6 (CC genotype Taq-1), OR=7.5 (AA genotype Cdx-1)
None
Key Statistics
2
Studi
120
Peserta
↑
Positive
D
Peringkat
Referenced Papers
Biochemical pharmacology
2026
Frontiers in bioengineering …
2025
8 sitasi
International journal of …
2025
1 sitasi
Skin appendage disorders
2025
Experimental dermatology
2024
5 sitasi
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Review
Regenerative therapy
2022
96 sitasi
Experimental dermatology
2020
10 sitasi
Indian journal of …
2020
5 sitasi
Nutrients
2019
23 sitasi
Skin appendage disorders
2018
88 sitasi
Journal of medicinal …
2018
37 sitasi
Journal of photochemistry …
2018
16 sitasi
Stem cell investigation
2017
53 sitasi
TheScientificWorldJournal
2014
14 sitasi
Experimental dermatology
2003
35 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 250-500 mg/day solubilized keratin
Batas atas: Not established
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | -- |
| biotin, collagen peptides, solubilized keratin MSM, choline-stabilized orthosilicic acid | -- | Positive | -- |
| USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 60 |
| None | -- | Mixed | -- |
| None | 8.7 weeks | Positive | -- |
Waktu terbaik diminum: With meals
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Generally well-tolerated
- ⚠ Rare gastrointestinal discomfort
Interaksi yang Diketahui
- ● No significant drug interactions documented
Asupan atas yang dapat ditoleransi: Not established
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Keratin help with Hair, Skin & Nails Health?
Based on 2 studies with 120 participants, there is preliminary evidence that needs more research that Keratin may support Hair, Skin & Nails Health management. Our evidence grade is D (Very Early Research).
How much Keratin should I take for Hair, Skin & Nails Health?
Studies have used various dosages. A commonly studied range is 250-500 mg/day solubilized keratin. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Keratin?
Reported side effects may include Generally well-tolerated, Rare gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Keratin and Hair, Skin & Nails Health?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 120 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Hair, Skin & Nails Health
References
- [1] Majid Manzoor et al.. Biochem Pharmacol. 2026. TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis. doi:10.1016/j.bcp.2026.117764 PubMed
- [2] Yukun Liu et al.. Front Bioeng Biotechnol. 2025. Subcutaneous injection of genetically engineered exosomes for androgenic alopecia treatment. doi:10.3389/fbioe.2025.1614090 PubMed
- [3] David Broadley et al.. Int J Cosmet Sci. 2025. A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: Insights from … doi:10.1111/ics.70035 PubMed
- [4] Ines Zaraa et al.. Skin Appendage Disord. 2025. Nail Supplements: When, How, and Why? doi:10.1159/000541048 PubMed
- [5] Jung Ok Lee et al.. Exp Dermatol. 2024. AP collagen peptides (APCPs) promote hair growth by activating the GSK-3β/β-catenin pathway and improve hair condition. doi:10.1111/exd.15137 PubMed
- [6] Yusuke Shimizu et al.. Regen Ther. 2022. Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature. doi:10.1016/j.reth.2022.10.005 PubMed
- [7] Ralf Paus et al.. Exp Dermatol. 2020. Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? doi:10.1111/exd.14156 PubMed
- [8] Iman Seleit et al.. Indian J Dermatol. 2020. Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss. doi:10.4103/ijd.IJD_482_18 PubMed
- [9] Marialuisa Piccolo et al.. Nutrients. 2019. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. doi:10.3390/nu11123041 PubMed
- [10] Jessica Cervantes et al.. Skin Appendage Disord. 2018. Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature. doi:10.1159/000477671 PubMed
- [11] Gian Carlo Tenore et al.. J Med Food. 2018. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … doi:10.1089/jmf.2017.0016 PubMed
- [12] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [13] Suruchi Garg et al.. Stem Cell Investig. 2017. Platelet-rich plasma-an 'Elixir' for treatment of alopecia: personal experience on 117 patients with review of literature. doi:10.21037/sci.2017.06.07 PubMed
- [14] Christina Beer et al.. ScientificWorldJournal. 2014. A clinical trial to investigate the effect of Cynatine HNS on hair and nail parameters. doi:10.1155/2014/641723 PubMed
- [15] Petra Clara Arck et al.. Exp Dermatol. 2003. Topical minoxidil counteracts stress-induced hair growth inhibition in mice. doi:10.1034/j.1600-0625.2003.00028.x PubMed
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