What is the recommended dosage for Polypodium leucotomos?

General: 240-480 mg/day; Photoprotection: 480 mg/day (240 mg twice daily, 30-60 min before sun exposure)

What are the side effects of Polypodium leucotomos?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort (rare), Pruritus (rare).

What is Polypodium leucotomos and how may it support skin health?

Polypodium leucotomos extract (PLE, Fernblock) is derived from a tropical fern with demonstrated photoprotective properties. Multiple RCTs show oral PLE reduces UV-induced skin damage, erythema, and DNA damage. It is used as a systemic photoprotection supplement and has been studied for preventing polymorphic light eruption and melasma.

What dosage of Polypodium leucotomos has been studied for sun protection?

Clinical studies have used 240–480 mg of PLE per day, typically taken 30 minutes before sun exposure. A common dose is 240 mg twice daily. Studies show PLE increases the minimal erythema dose (MED) by approximately 2–3 fold, providing supplemental UV protection. It does not replace topical sunscreen.

What are the potential side effects of Polypodium leucotomos?

PLE is generally well tolerated in clinical trials with no significant adverse events reported. Mild gastrointestinal discomfort has been noted. It should not be used as a substitute for sunscreen or sun-protective clothing. Individuals with fern allergies should exercise caution. Long-term safety data beyond 6 months is limited.

Polypodium leucotomos
Polypodium leucotomos

specialty

También conocido como: PLE, Fernblock, Heliocare, Calaguala, Anapsos

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About

Polypodium leucotomos is a tropical fern extract that reduces UV-induced oxidative stress and DNA damage. A systematic review of 5 RCTs found oral PLE significantly increased the minimal erythema dose (MED) by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

How It Works

Tropical fern extract rich in phenolic compounds that reduce UV-induced oxidative stress; inhibits MMP-1 expression; suppresses UV-mediated COX-2 and AP-1 activation; reduces UV-induced DNA damage (cyclobutane pyrimidine dimers); may modulate Langerhans cell depletion from UV exposure.

Evidence For Conditions

Condición	Calificación	Estudios	Participantes
UV Protection (Internal Photoprotection)	B	5	250	Ver →
Hyperpigmentation	C	3	150	Ver →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort (rare)
Pruritus (rare)

Drug & Supplement Interactions

Immunosuppressants (may modulate immune function)
Photosensitizing medications (may modulate UV response)

Informe siempre a su profesional de salud sobre todos los suplementos que toma.Siempre informe a su profesional de salud sobre todos los suplementos que toma.

Related Ingredients

Pine Bark Extract (Pycnogenol) Nicotinamide MSM

Datos rápidos

Dosificación: General: 240-480 mg/day; Photoprotection: 480 mg/day (240 mg twice daily, 30-60 min before sun exposure)
Formas: capsule tablet
Fuentes naturales: Polypodium leucotomos fern (Central and South American tropical fern)
Límite superior: Generally well-tolerated up to 960 mg/day
Mejor momento: 30-60 minutes before sun exposure; can also be taken daily for baseline protection

Resumen de evidencia

UV Protection (Internal Photoprotection) B

Hyperpigmentation C

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.