What is the recommended dosage for Grape Seed Extract?

General: 100-300 mg/day; Skin Health: 100-400 mg/day standardized to 95% OPCs

What are the side effects of Grape Seed Extract?

Potential side effects include: Mild gastrointestinal discomfort, Headache (rare), Dizziness (rare).

What is grape seed extract and how may it support skin health?

Grape seed extract contains oligomeric proanthocyanidins (OPCs) with strong antioxidant activity. It may protect collagen and elastin from enzymatic degradation, improve microcirculation in the skin, and reduce UV-induced oxidative damage. Some clinical trials show benefits for skin elasticity, hyperpigmentation, and wound healing.

What dosage of grape seed extract has been studied for skin benefits?

Skin-related studies have used 100–400 mg of grape seed extract per day, standardized to 80–95% OPCs. Improvements in skin elasticity and melanin index were observed at 200 mg daily for 6–12 months. Chloasma (melasma) studies used 200 mg daily. Higher OPC standardization may correlate with greater efficacy.

What are the potential side effects of grape seed extract?

Grape seed extract is generally well tolerated. Mild side effects include headache, digestive discomfort, and sore throat. It may increase bleeding risk when combined with anticoagulants or antiplatelet drugs. Individuals with grape allergies should avoid this supplement. No serious adverse events have been reported in skin studies.

Grape Seed Extract
Grape Seed Extract

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يُعرف أيضاً بـ: OPC, Oligomeric Proanthocyanidins, Vitis vinifera Extract, GSE

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About

Grape seed extract is a rich source of oligomeric proanthocyanidins (OPCs) that bind and stabilize collagen and elastin fibers with 20x the antioxidant capacity of vitamin C. An RCT found grape seed extract improved skin elasticity and melanin index in women with chloasma after 6 months.

How It Works

Rich source of oligomeric proanthocyanidins (OPCs) that bind and stabilize collagen and elastin fibers; potent free radical scavenger with 20x antioxidant capacity of vitamin C and 50x of vitamin E; may inhibit UV-induced MMP expression and support microvascular integrity in skin.

Evidence For Conditions

الحالة	التقييم	الدراسات	المشاركون
Aging Skin & Wrinkles	C	5	280	عرض →
Hyperpigmentation	C	3	180	عرض →

Side Effects

Mild gastrointestinal discomfort
Headache (rare)
Dizziness (rare)

Drug & Supplement Interactions

Anticoagulants (may have antiplatelet effects)
NSAIDs (may have additive effects)
Iron supplements (tannins may reduce absorption)

أخبر مقدم الرعاية الصحية دائماً بجميع المكملات التي تتناولها.

Related Ingredients

Green Tea Extract Aloe Vera Turmeric (Curcumin) Saw Palmetto

حقائق سريعة

الجرعة: General: 100-300 mg/day; Skin_Health: 100-400 mg/day standardized to 95% OPCs
الأشكال الدوائية: capsule tablet liquid extract
المصادر الطبيعية: Grape seeds, Red wine, Grape skins
الحد الأعلى: Generally well-tolerated up to 600 mg/day
أفضل وقت: With or without food; well absorbed

ملخص الأدلة

Aging Skin & Wrinkles C

Hyperpigmentation C

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