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Niacinamide
Niacinamide

vitamin

别名: Nicotinamide, Vitamin B3, Niacin amide

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About





            

                
Niacinamide is the amide form of vitamin B3 that supports NAD+/NADH coenzyme production, strengthens the epidermal lipid barrier by stimulating ceramide and fatty acid synthesis, and inhibits melanosome transfer from melanocytes to keratinocytes. The landmark ONTRAC trial found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% in high-risk individuals.

            

        

        

        
        
        

            

  
How It Works





            

                
Amide form of vitamin B3 that supports NAD+/NADH coenzyme production; strengthens the epidermal lipid barrier by stimulating ceramide and fatty acid synthesis; inhibits melanosome transfer from melanocytes to keratinocytes (reducing hyperpigmentation); suppresses NF-kB-mediated inflammatory pathways in skin.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Acne
                                    
                                
                                
                                    A

                                
                                
                                    15
                                
                                
                                    1200
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        UV Protection (Internal Photoprotection)
                                    
                                
                                
                                    A

                                
                                
                                    5
                                
                                
                                    686
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally well-tolerated (no flushing unlike niacin)
                
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                    Mild gastrointestinal discomfort at high doses
                
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                    Rare hepatotoxicity at very high doses (> 3,000 mg/day)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticonvulsants (carbamazepine — may increase niacinamide levels)
                
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                    Hepatotoxic drugs (potential additive liver effect at high doses)
                
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                    Isoniazid (competes for NAD+ pathways)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin C
                    
                
                
                
                    Vitamin E
                    
                
                
                
                    Vitamin A (Retinol)
                    
                
                
                
                    Vitamin D
                    
                
                
                
                    Biotin
                    
                
                
            

        

        
    


    
    












    

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