What is the recommended dosage for Nicotinamide?

General Skin Barrier: 500-1,500 mg/day; Skin Cancer Chemoprevention: 500 mg twice daily (1,000 mg/day total)

What are the side effects of Nicotinamide?

Potential side effects include: Generally well-tolerated (no flushing), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses.

What is nicotinamide and how may it protect skin from cancer?

Nicotinamide (niacinamide, vitamin B3) enhances DNA repair in UV-damaged skin cells by replenishing cellular NAD+ levels depleted by UV exposure. The landmark ONTRAC trial demonstrated that 500 mg twice daily reduced new non-melanoma skin cancers by 23% in high-risk patients. This is one of the best-evidenced cancer-preventive supplements available.

What dosage of nicotinamide has been studied for skin cancer prevention?

The ONTRAC trial used 500 mg of nicotinamide twice daily (1,000 mg/day) for 12 months in patients with a history of non-melanoma skin cancer. Benefits were observed during the supplementation period but disappeared within 6 months of cessation. Continuous supplementation may be needed for ongoing protection.

What are the potential side effects of nicotinamide for skin protection?

Nicotinamide at 1,000 mg daily is generally well tolerated and does not cause the flushing associated with niacin. Mild gastrointestinal effects may occur. Very high doses (above 3,000 mg daily) may cause liver toxicity. Nicotinamide does not replace sun protection measures including sunscreen, protective clothing, and avoiding peak UV hours.

Nicotinamide
Nicotinamide

specialty

Còn được gọi là: Nicotinamide (high-dose oral), Vitamin B3 (oral oncology dose)

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Nicotinamide at chemoprevention doses replenishes cellular NAD+ depleted by UV-induced PARP activation, enhancing cellular energy for DNA repair. The landmark ONTRAC trial (386 patients, NEJM 2015) found nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals.

How It Works

Amide form of vitamin B3 (distinct from niacinamide in dosing context); replenishes cellular NAD+ depleted by UV-induced PARP activation; enhances cellular energy for DNA repair; supports immune surveillance of skin cancer precursors; strengthens skin barrier ceramide synthesis.

Evidence For Conditions

Tình trạng	Xếp hạng	Nghiên cứu	Người tham gia
UV Protection (Internal Photoprotection)	A	5	686	Xem →

Side Effects

Generally well-tolerated (no flushing)
Mild gastrointestinal discomfort at high doses
Rare hepatotoxicity at very high doses

Drug & Supplement Interactions

Anticonvulsants (carbamazepine — may increase levels)
Isoniazid (competes for NAD+ pathways)
Hepatotoxic drugs (potential additive liver effect at high doses)

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Related Ingredients

Pine Bark Extract (Pycnogenol) Polypodium leucotomos MSM

Thông tin nhanh

Liều lượng: General_Skin_Barrier: 500-1,500 mg/day; Skin_Cancer_Chemoprevention: 500 mg twice daily (1,000 mg/day total)
Dạng bào chế: tablet capsule
Nguồn tự nhiên: Poultry, Fish, Mushrooms, Peanuts (oncology doses require supplementation)
Giới hạn trên: Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Thời điểm tốt nhất: With meals; split into 2 doses for chemoprevention

Tóm tắt bằng chứng

UV Protection (Internal Photoprotection) A

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