What is the recommended dosage for Vitamin E?

General: 15 mg (22.4 IU)/day (RDA); Skin Health: 15-400 IU/day

What are the side effects of Vitamin E?

Potential side effects include: Generally well-tolerated at recommended doses, Increased bleeding risk at high doses (> 400 IU/day), Nausea and diarrhea (rare).

What is vitamin E and how may it support skin health?

Vitamin E is a fat-soluble antioxidant that protects cell membranes from oxidative damage, including UV-induced lipid peroxidation in skin. When combined with vitamin C, oral vitamin E has shown synergistic photoprotective effects. It may also support skin barrier function and wound healing.

What dosage of vitamin E has been studied for skin outcomes?

Skin-related studies have used 400–1,000 IU of vitamin E (alpha-tocopherol) per day, often combined with vitamin C. The RDA is 15 mg (22.4 IU). Photoprotection studies typically combined 1,000 IU vitamin E with 2,000 mg vitamin C. The mixed tocopherol form may be more beneficial than alpha-tocopherol alone.

What are the potential side effects of vitamin E supplements?

High-dose vitamin E (above 400 IU daily) has been associated with increased bleeding risk and possibly increased all-cause mortality. It may interact with blood thinners and antiplatelet drugs. Topical vitamin E can cause contact dermatitis in some individuals. The tolerable upper intake level is 1,000 mg (1,500 IU natural form).

Vitamin E
Vitamin E

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يُعرف أيضاً بـ: Alpha-Tocopherol, d-Alpha-Tocopherol, Tocopheryl Acetate, Mixed Tocopherols

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Vitamin E is the major lipid-soluble antioxidant in human skin, concentrated in the stratum corneum. It accumulates in cell membranes and protects polyunsaturated fatty acids from lipid peroxidation. Research suggests vitamin E works synergistically with vitamin C for photoprotection, and combined oral supplementation is associated with reduced sunburn response (higher MED).

How It Works

Fat-soluble antioxidant that accumulates in cell membranes and protects polyunsaturated fatty acids from lipid peroxidation; supports skin barrier function by maintaining stratum corneum lipid integrity; works synergistically with vitamin C to regenerate oxidized tocopherols.

Evidence For Conditions

الحالة	التقييم	الدراسات	المشاركون
UV Protection (Internal Photoprotection)	C	8	600	عرض →
Aging Skin & Wrinkles	C	6	350	عرض →

Side Effects

Generally well-tolerated at recommended doses
Increased bleeding risk at high doses (> 400 IU/day)
Nausea and diarrhea (rare)

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
Statins and niacin (may reduce HDL-raising benefit)
Chemotherapy and radiation (antioxidant interference — consult oncologist)

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Related Ingredients

Vitamin C Vitamin A (Retinol) Vitamin D Biotin Niacinamide

حقائق سريعة

الجرعة: General: 15 mg (22.4 IU)/day (RDA); Skin_Health: 15-400 IU/day
الأشكال الدوائية: softgel capsule liquid topical
المصادر الطبيعية: Almonds, Sunflower seeds, Wheat germ oil, Hazelnuts, Spinach, Avocado
الحد الأعلى: 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)
أفضل وقت: With meals containing fat for better absorption

ملخص الأدلة

UV Protection (Internal Photoprotection) C

Aging Skin & Wrinkles C

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